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TC-DAPK 6

CAS No. 315694-89-4

TC-DAPK 6( —— )

Catalog No. M33509 CAS No. 315694-89-4

TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TC-DAPK 6
  • Note
    Research use only, not for human use.
  • Brief Description
    TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.
  • Description
    TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP).
  • In Vitro
    TC-DAPK 6 is found to be the most potent Death-associated protein kinase (DAPK) inhibitor with enzyme selectivity. When assayed with 10 μM ATP, the IC50 values for DAPK1 and DAPK3 are 69 and 225 nM, respectively. TC-DAPK 6 also inhibits p70S6K (1 μM < IC50< 10 μM).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    DAPK
  • Recptor
    DAPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    315694-89-4
  • Formula Weight
    276.29
  • Molecular Formula
    C17H12N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 18.67 mg/mL (67.57 mM)
  • SMILES
    C(=C1C(=O)OC(C=CC2=CC=CC=C2)=N1)C=3C=CC=NC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Okamoto M, et al. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J Med Chem. 2009 Nov 26;52(22):7323-7.?
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